Zooplankton is a community that occupies a key position in pelagic food webs as a link between primary producers and the highest trophic levels. It has been scarcely studied in the central area of Venezuela. In this survey, we analyze spatial and temporal variations of composition and density of zooplankton, and its relationship with the environmental conditions of the coastal zone between Chirimena and Puerto Francés, Miranda state, Venezuela. Sampling was carried out monthly from June 2014 to March 2015, by performing horizontal trawls with a standard zooplankton net. To analyze the results, hypothesis tests and multivariate analyses were applied. The surveyed area showed two seasons: rainy and drought, which by themselves do not explain the temporal variation of the estimated variables. This zooplankton community had a richness of 121 species with representatives of 12 phyla, a typical feature of the coastal zooplankton community in the Caribbean Sea. The most representative organisms in terms of richness were copepods, cnidarians, and decapods. Zooplankton abundance had maximum values between June and September with an average of 98 ± 25 ind/m3 and the lowest between February and March with an average of 23 ± 13 ind/m3, which are characteristic densities of oligotrophic waters.